Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma in a Patient with Epidermodysplasia Verruciformis
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چکیده
منابع مشابه
Merkel cell polyomavirus-positive Merkel cell carcinoma in a patient with epidermodysplasia verruciformis.
Epidermodysplasia verruciformis (EV) is a rare auto somal recessive disease characterised by abnormal susceptibility to disease-specific human papillomaviruses (HPVs), possibly due to suppressed cellular innate im munity. EVER1/TMC6 or EVER2/TMC8 gene mutations are often found in EV (1). All patients with EV usually have similar skin lesions from their childhood, involving disseminated flat w...
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We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
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The RNA viruses hepatitis C virus and human T-cell lymphotropic virus type I (or human T-cell leukaemia virus type 1), and the DNA viruses hepatitis B virus, high-risk human papillomaviruses, human herpes virus-8 (Kaposi’s sarcoma-associated herpes virus) and Epstein Barr virus are acknowledged as carcinogenic to humans. Human polyomaviruses have oncogenic potentials in cell cultures and animal...
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INTRODUCTION Merkel cell carcinoma (MCC) is a rare and highly aggressive malignancy of the skin which occurs mainly in old people and is very uncommon in young individuals. A new tumor virus belonging to the Polyomaviridae family; Merkel Cell Polyomavirus (MCPyV) has recently been identified in more than 80% of MCCs. CASE PRESENTATION We conducted a retrospective review on the archives of the...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2015
ISSN: 0001-5555
DOI: 10.2340/00015555-1868